Atherosclerosis Initiation Modeled as an Inflammatory Process
نویسندگان
چکیده
منابع مشابه
Atherosclerosis Initiation Modeled as an Inflammatory Process
In this work we study the inflammatory process resulting in the development of atherosclerosis. We develop a oneand two-dimensional models based on reaction-diffusion systems to describe the set up of a chronic inflammatory response in the intima of an artery vessel wall. The concentration of the oxidized low density lipoproteins (ox-LDL) in the intima is the critical parameter of the model. Lo...
متن کاملAtherosclerosis--an inflammatory process.
I recent years, it has become apparent that atherosclerosis is a chronic inflammatory process affecting largeand medium-sized arteries throughout the cardiovascular system. The rate of progression is variable with the lesions occurring primarily at sites of low shear stress or increased turbulence, ie, at sites of bifurcation or curvature of the vessels. The early stages of the process mimic ch...
متن کاملAtherosclerosis as an inflammatory disease: implications for therapy.
Cardiovascular disease remains a leading cause of mortality in the United States despite the use of new pharmacologic therapy, lifestyle modifications, and different coronary interventions. Atherosclerosis represents a wide variety of pathologic lesions with different clinical impacts. In this review, we address the current understanding of the pathophysiological mechanisms underlying the devel...
متن کاملMathematical modelling of atherosclerosis as an inflammatory disease.
Atherosclerosis is an inflammatory disease. The atherosclerosis process starts when low-density lipoproteins (LDLs) enter the intima of the blood vessel, where they are oxidized (ox-LDLs). The anti-inflammatory response triggers the recruitment of monocytes. Once in the intima, the monocytes are transformed into macrophages and foam cells, leading to the production of inflammatory cytokines and...
متن کاملAdipokines, diabetes and atherosclerosis: an inflammatory association
Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular events. Inflammation process is currently recognized as responsible for the development and maintenance of diverse chronic diseases, including diabetes and atherosclerosis. Considering that adipose tissue is an important source of adipok...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mathematical Modelling of Natural Phenomena
سال: 2007
ISSN: 0973-5348
DOI: 10.1051/mmnp:2008022